Overall sight to brain
The human brain contains roughly 90-100 billion neurons. The number of synaptic connections that neurons establish between themselves can sometimes reach up to 1000 for per neuron [1].
Taking into account that human neuron cells cannot undergo the mitosis division process, maintaining of brain’s normal physiological process is mainly depend on new synaptic connections. Healthy functioning of the axon and dendrite connections of neurons can only be maintained with the optimal presence of neuromodulators. So, optimum neurotransmitter supply for brain should be taken with daily nutrients or nutraceuticals [2].
Mechanism of action of The Golden Thinker
Most individuals consume inadequate amounts of choline, tyrosine, thiamine, L-carnitine, pantothenic acid and vitamin-B12, as a result of deficiency of these molecules some unexpected situations may occur and cause lower performance for us.
For optimal maintaining of your mental and physical activity, we developed new brand supplement; The Golden Thinker.
Fundamental molecule for our body: Choline bitartrate
Choline plays a vital role in many physiological pathways, including neurotransmitter synthesis cell-membrane signaling, lipid transport and methyl-group metabolism (homocysteine reduction) [3].
Daily adequate choline intake is essential for healthy nervous system, because brain cells need to acetylcholine, derived from choline, for memory processing and synaptic communication. Unsupplied choline deficiency may cause weakened brain performance, muscle impairment [4] and exacerbates fatty liver [5].
Several effects of choline
Researchers have also documented that an optimum choline intake during the pregnancy, associated with mental health of the baby. During the pregnancy or lactating woman need to plenty of choline, like as the men who consume choline more than his body source.
Some of the choline included nutrient are spinach, wheat germ, milk, and shrimp. Clearly, a varied diet of whole, unrefined foods is best, but if you’re not regularly eating these foods, supplemental choline can fill this blank [6].
Choline is one the most required molecule for improved mental focusing/memory, adequate nutrition the period of pregnancy/lactating, sticking with your exercise regimen and physical activity, and also help your heart and liver.
What is the role of L-tyrosine
Tyrosine derived catecholamines are dopamine, norepinephrine and epinephrine which enroll crucial role in the nervous system.
Although tyrosine is a non-essential amino acid, it is produced by the body when insufficient amounts are ingested by daily untaken nutrients [7].
However, tyrosine pairs with phenylalanine to form an amino acid pair, and phenylalanine is an essential amino acid, meaning that it must be ingested in food.
Therefore, lack of the tyrosine should be supplied by taking L-tyrosine form which can cross blood/brain barrier. The World Health Organization recommended daily amount for the tyrosine is set as 25 mg/kg [8].
Dopamine, norepinephrine and epinephrine synthesis from the precursor amino acid: Tyrosine
References1.
Raichle, M.E., et al., A default mode of brain function. Proceedings of the National Academy of Sciences, 2001. 98(2): p. 676-682.2.
Hoebel, B.G., Brain neurotransmitters in food and drug reward. The American journal of clinical nutrition, 1985. 42(5): p. 1133-1150.3.
Penry, J.T. and M.M. Manore, Choline: an important micronutrient for maximal endurance-exercise performance? International journal of sport nutrition and exercise metabolism, 2008. 18(2): p. 191-203.4.
Zeisel, S.H., Choline deficiency. The Journal of nutritional biochemistry, 1990. 1(7): p. 332-349.5.
Raubenheimer, P.J., M.J. Nyirenda, and B.R. Walker, A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. Diabetes, 2006. 55(7): p. 2015-2020.6.
Zeisel, S.H., Choline: an important nutrient in brain development, liver function and carcinogenesis. Journal of the American College of Nutrition, 1992. 11(5): p. 473-481.7. Gibson, C. and R. Wurtman, Physiological control of brain norepinephrine synthesis by brain tyrosine concentration. Life Sciences, 1978. 22(16): p. 1399-1405.8. Organization, W.H. Protein and amino acid requirements in human nutrition.
[cited 2019October];Availablefrom:https://apps.who.int/iris/bitstream/handle/10665/43411/WHO_TRS_935_eng.pdf?ua=1PROTEIN
